Ang D, Sui Y, Cui H, Yu Y Experimental study on anaphylaxis of qingkailing injection and its components on Beagle dogs. J Tradit Chin Med 32: 641645. 16. Wang Z, Wang D, Yu Y, Li Y, Sui Y, et al. Experimental model of histamine-induced anaphylactoid reaction on beagle dogs. Zhongguo Zhong Yao Za Zhi 36: 18421844. 17. Liang A, Li C, Hao R, Cao C, Yi Y, et al. . Zhongguo Zhong Yao Za Zhi 35: 23282333. 18. He P, Li F, Tang R, Li Y, Hao W, et al. . Zhongguo Zhong Yao Za Zhi 37: 18801884. 9 Anaphylactoid Reaction of Vitamin K1 Injection 19. Vo T, Kong C, Kim S Inhibitory effects of chitooligosaccharides on degranulation and cytokine generation in rat basophilic leukemia RBL-2H3 cells CARBOHYDRATE POLYMERS 84: 649655 20. Na HJ, Moon PD, Lee HJ, Kim HR, Chae HJ, et al. Regulatory effect of atopic allergic reaction by Carpopeltis affinis. J Ethnopharmacol 101: 4348. 21. Nishikawa H, Kitani S Gangliosides inhibit bee venom melittin cytotoxicity but not phospholipase A-induced degranulation in mast cells. Toxicol Appl Pharmacol 252: 228236. 22. Ng W, Lobach AR, Zhu X, Chen X, Liu F, et al. Animal models 23115181 of idiosyncratic drug reactions. Adv Pharmacol 63: 81135. 23. Shenton JM, Chen J, Uetrecht JP Animal models of idiosyncratic drug reactions. Chem Biol Interact 150: 5370. 24. Huang FH, Zhang XY, Zhang LY, Li Q, Ni B, et al. Mast cell degranulation induced by chlorogenic acid. Acta Pharmacol Sin 31: 849854. 25. Funaba M, Ikeda T, Abe M Degranulation in RBL-2H3 cells: regulation by calmodulin pathway. Cell Biol Int 27: 879885. 26. Sun W, Li Y, Wang N, Du F, Hao W, et al. . Zhongguo Zhong Yao Za Zhi 36: 18741878. 27. Wang Z, Wang D, Yu Y, Sui Y, Cui H, et al. . Zhongguo Zhong Yao Za Zhi 36: 18701873. 28. Weiss RB, Donehower RC, Wiernik PH, Ohnuma T, Gralla RJ, et al. Hypersensitivity reactions from taxol. J Clin Oncol eight: 12631268. 10 ~~ ~~ Endothelial cells are steadily exposed to a selection of physical and biomechanical stimuli. 3 primary hemodynamic forces act on endothelium: a) the radial stress created by the hydrostatic blood forces, b) circumferential stretch or tension resulting by intercellular connections among the endothelial cells, and c) shear anxiety, the frictional force created by blood flow. These forces have been shown to induce various cellular events; in particular the presence of low shear, non-laminar flow is able to induce modifications in gene expression profile that predispose the endothelium to the initiation and improvement of atherosclerotic lesions. Non-laminar flow Autophagy promotes alterations to endothelial gene expression, cytoskeletal arrangement, wound repair, leukocyte adhesion at the same time as for the vasoreactive, oxidative and inflammatory states of the artery wall. Disturbed shear anxiety also influences the internet site selectivity of atherosclerotic plaque formation too as its related vessel wall remodelling, which can have an effect on plaque vulnerability. Current research have highlighted that the placement of a stent Epigenetics against the artery wall may perhaps influence the arterial mechanical atmosphere in 17493865 extremely profound way. Stent application may possibly directly injured endothelium through a mechanical stretching action that produces endothelial harm and denudation. Additionally, changes in flow patterns immediately after stent positioning have already been observed in experimental/computational flow study and include large-scale vortex formation and strut-spacing dependent flow stagnation. The low shear stresses associated with flow stagnation could probably induce, together with endothel.Ang D, Sui Y, Cui H, Yu Y Experimental study on anaphylaxis of qingkailing injection and its elements on Beagle dogs. J Tradit Chin Med 32: 641645. 16. Wang Z, Wang D, Yu Y, Li Y, Sui Y, et al. Experimental model of histamine-induced anaphylactoid reaction on beagle dogs. Zhongguo Zhong Yao Za Zhi 36: 18421844. 17. Liang A, Li C, Hao R, Cao C, Yi Y, et al. . Zhongguo Zhong Yao Za Zhi 35: 23282333. 18. He P, Li F, Tang R, Li Y, Hao W, et al. . Zhongguo Zhong Yao Za Zhi 37: 18801884. 9 Anaphylactoid Reaction of Vitamin K1 Injection 19. Vo T, Kong C, Kim S Inhibitory effects of chitooligosaccharides on degranulation and cytokine generation in rat basophilic leukemia RBL-2H3 cells CARBOHYDRATE POLYMERS 84: 649655 20. Na HJ, Moon PD, Lee HJ, Kim HR, Chae HJ, et al. Regulatory effect of atopic allergic reaction by Carpopeltis affinis. J Ethnopharmacol 101: 4348. 21. Nishikawa H, Kitani S Gangliosides inhibit bee venom melittin cytotoxicity but not phospholipase A-induced degranulation in mast cells. Toxicol Appl Pharmacol 252: 228236. 22. Ng W, Lobach AR, Zhu X, Chen X, Liu F, et al. Animal models 23115181 of idiosyncratic drug reactions. Adv Pharmacol 63: 81135. 23. Shenton JM, Chen J, Uetrecht JP Animal models of idiosyncratic drug reactions. Chem Biol Interact 150: 5370. 24. Huang FH, Zhang XY, Zhang LY, Li Q, Ni B, et al. Mast cell degranulation induced by chlorogenic acid. Acta Pharmacol Sin 31: 849854. 25. Funaba M, Ikeda T, Abe M Degranulation in RBL-2H3 cells: regulation by calmodulin pathway. Cell Biol Int 27: 879885. 26. Sun W, Li Y, Wang N, Du F, Hao W, et al. . Zhongguo Zhong Yao Za Zhi 36: 18741878. 27. Wang Z, Wang D, Yu Y, Sui Y, Cui H, et al. . Zhongguo Zhong Yao Za Zhi 36: 18701873. 28. Weiss RB, Donehower RC, Wiernik PH, Ohnuma T, Gralla RJ, et al. Hypersensitivity reactions from taxol. J Clin Oncol eight: 12631268. ten ~~ ~~ Endothelial cells are steadily exposed to a array of physical and biomechanical stimuli. Three key hemodynamic forces act on endothelium: a) the radial pressure created by the hydrostatic blood forces, b) circumferential stretch or tension resulting by intercellular connections in between the endothelial cells, and c) shear tension, the frictional force produced by blood flow. These forces happen to be shown to induce various cellular events; in particular the presence of low shear, non-laminar flow is able to induce modifications in gene expression profile that predispose the endothelium towards the initiation and improvement of atherosclerotic lesions. Non-laminar flow promotes alterations to endothelial gene expression, cytoskeletal arrangement, wound repair, leukocyte adhesion also as towards the vasoreactive, oxidative and inflammatory states of the artery wall. Disturbed shear stress also influences the internet site selectivity of atherosclerotic plaque formation too as its related vessel wall remodelling, which can affect plaque vulnerability. Current studies have highlighted that the placement of a stent against the artery wall may perhaps affect the arterial mechanical atmosphere in 17493865 pretty profound way. Stent application may directly injured endothelium by way of a mechanical stretching action that produces endothelial harm and denudation. Moreover, alterations in flow patterns after stent positioning have already been observed in experimental/computational flow study and contain large-scale vortex formation and strut-spacing dependent flow stagnation. The low shear stresses linked with flow stagnation could most likely induce, with each other with endothel.