lenectomy and cholecystectomy a year before as a result of epigastric pain and splenomegaly because of -thalassemia and chronic hepatitis B. She had higher platelet count and good lupus anticoagulant. Results: In case 1, With anticoagulation and chemotherapy, the intracranial sinus thrombosis was cleared 2 months later. The thrombosis did not recur for four years now and his MM was in partial remission. In case 2, anticoagulation and chemotherapy for MM had to become suspended continuously because of recurrent upper digestive bleeding. Her MM was in remission just after courses of chemotherapy. But, however, she died of delayed therapy for PE soon after she discontinued anticoagulants and had diarrhea. The report right here has got informed consent from the patient and their relatives. Brd Inhibitor web Conclusions: DVT is often the very first presentation of MM and need to be paid attention to and serum Ig concentration needs to be checked. Effective treatment of MM together with anticoagulation therapy is useful for the clearance of thrombosis.Strategies:FIGURE 1 Left internal giugular vein thrombosis A 35 y-o man reported dysphagia, EGDS: esophagus ulcers, thyroid echography: thoracic mass compressing proximal borders. Vascular ultrasound: thrombosis of left internal giugular, subclavian, axillary and brachial veins; he started enoxaparin 4000 IU x2/die. CT: solid anterior-superior mediastinum vascularized mass (16 x 13 cm) incorporating good thoracic vessels with 20 cm cranio-caudalPO188|”Heparin Failure” in Seminoma-related Dramatic Hypercoagulable Melieu and Extended Vein Thrombosis: Is it BEP Protocol Ongoing Accountable A.M. Fioretti1; T. Leopizzi1; L. Palermo2; V. Lorusso2; S. Olivalongitudinal extension with trachea dislocation. PET-CT: enormous superior-anterior mediastinum pathologicalF-FDG accumulationsuggestive for malignancy. Lung perfusion scan: absence of left lung perfusion. Angio-CT: showed compression of pulmonary artery trunk and of branches. He presented marked BRD9 Inhibitor Purity & Documentation asthenia, sweating and presyncope. D-dimer: 6026 g/L, NT-proBNP: 1417 pg/mL. Mediastinum biopsy exhibited seminoma (ki67+: 65 ), he began BEP Protocol (etoposide, cisplatin, bleomycin), till now.Cardio-Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari,Italy; 2Medical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy Background: TEV is really a typical cancer complication with 20 incidence. Aims: LMWH could be the common therapy for efficacy, security and ease of use. Nonetheless, some scenarios are deeply difficult for intercurrent prothrombotic anticancer drugs.ABSTRACT839 of|Final results:secondary prevention. It is actually much less clear the efficacy of DOACs s in individuals with important thrombophilia. Aims: The aim of our study was to evaluate the efficacy, in terms of VTE prevention, and security, when it comes to absence of bleeding complications, in individuals with main thrombophilia in comparison to nonthrombophilic individuals candidate to long-term anticoagulation for recurrent VTE. Techniques: We evaluated consecutive patients who needed longterm anticoagulation for recurrent VTE, treated with DOACs, and compared the outcomes involving individuals affected by main thrombophilia and non-thrombophilic individuals. All individuals presented a minimum of two thrombotic events. Main thrombophilia was defined because the presence of physiologic inhibitors deficiency (protein C, protein S and antithrombin; homozygous Element V Leiden, homozygous Element II G20210A, combined heterozygosity of these defects. Final results:FIGURE two Partial recalization