Autoimmune thrombocytopenia and pernicious anemia has also been reported to be enhanced [16,67].Conclusion Gestational pemphigoid is often a uncommon skin disorder in pregnancy. The serious itching and blistering caused by the disease could be quite debilitating. The diagnosis of PG is produced within a specialized care setting at a dermatology department. Due to the fact PG is associated using a threat of prematurity and fetal development restriction, pregnancy monitoring by an obstetrician is encouraged. CXCR3 manufacturer Mothers with PG need to be informed in the natural course from the disease, great fetal prognosis, the possibility of relapses soon after delivery, plus the threat of relapses in subsequent pregnancies and with hormonal contraception.Huilaja et al. Orphanet Journal of Rare Diseases 2014, 9:136 http://ojrd/content/9/1/Page 7 ofAbbreviations PG: Pemphigoid gestationis, gestational pemphigoid; BP: Bullous pemphigoid; BP180: Bullous pemphigoid antigen 180; BP230: Bullous pemphigoid antigen 230; MHC: Main histocompatibility complicated; HLA: Human leucocyte antigen; IgG: Immunoglobulin G; AEP: Atopic eruption of pregnancy; PEP: Polymorphic eruption of pregnancy; ICP: Intrahepatic cholestasis of Kinesin Gene ID pregnancypeting interests The authors declare that they’ve no competing interests.Authors’ contributions Authors contributed equally to this review. All authors have read and approved the final version from the manuscript. Author specifics 1 Division of Dermatology, Healthcare Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland. 2Department of Obstetrics and Gynecology, University of Oulu, Oulu University Hospital, Oulu, Finland. Received: 20 May 2014 Accepted: 19 August 2014 Published: 2 SeptemberReferences 1. Schmidt E, Zillikens D: Pemphigoid diseases. Lancet 2013, 381(9863):32032. 2. Holmes RC, Black MM: The precise dermatoses of pregnancy. J Am Acad Dermatol 1983, eight(three):40512. 3. Nanda A, Dvorak R, Al-Saeed K, Al-Sabah H, Alsaleh QA: Spectrum of autoimmune bullous ailments in Kuwait. Int J Dermatol 2004, 43(12):87681. four. Bernard P, Vaillant L, Labeille B, Bedane C, Arbeille B, Denoeux JP, Lorette G, Bonnetblanc JM, Prost C: Incidence and distribution of subepidermal autoimmune bullous skin ailments in three French regions. Bullous Diseases French Study Group. Arch Dermatol 1995, 131(1):482. five. Bertram F, Brocker E, Zillikens D, Schmidt E: Prospective evaluation on the incidence of autoimmune bullous disorders in Lower Franconia, Germany. J Dtsch Dermatol Ges 2009, 7(five):43439. 6. Ambros-Rudolph CM, Mullegger RR, Vaughan-Jones SA, Kerl H, Black MM: The specific dermatoses of pregnancy revisited and reclassified: benefits of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol 2006, 54(3):39504. 7. Semkova K, Black M: Pemphigoid gestationis: current insights into pathogenesis and treatment. Eur J Obstet Gynecol Reprod Biol 2009, 145(two):13844. eight. Shornick JK, Meek TJ, Nesbitt LT Jr, Gilliam JN: Herpes gestationis in blacks. Arch Dermatol 1984, 120(4):51113. 9. Kneisel A, Hertl M: Autoimmune bullous skin illnesses. Portion 1: clinical manifestations. J Dtsch Dermatol Ges 2011, 9(10):84457. ten. Takatsuka Y, Komine M, Ohtsuki M: Pemphigoid gestationis with a comprehensive hydatidiform mole. J Dermatol 2012, 39(five):47476. 11. Djahansouzi S, Nestle-Kraemling C, Dall P, Bender HG, Hanstein B: Herpes gestationis could present itself as a paraneoplastic syndrome of choriocarcinoma-a case report. Gynecol Oncol 2003, 89(2):33437. 12. Castro LA, Lundell RB, Krause PK, Gibson LE:.