Product Name :
Androgen receptor antagonist 1
Description:
Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC50 of 59 nM. Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.
CAS:
1338812-36-4
Molecular Weight:
416.90
Formula:
C21H25ClN4O3
Chemical Name:
N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxamide
Smiles :
CC1(C)C(NC(=O)C2C=NN(CCO)C=2)C(C)(C)C1OC1=CC(Cl)=C(C=C1)C#N
InChiKey:
HJJNHDLYWZTKGQ-UHFFFAOYSA-N
InChi :
InChI=1S/C21H25ClN4O3/c1-20(2)18(25-17(28)14-11-24-26(12-14)7-8-27)21(3,4)19(20)29-15-6-5-13(10-23)16(22)9-15/h5-6,9,11-12,18-19,27H,7-8H2,1-4H3,(H,25,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Moxetumomab} medchemexpress|{Moxetumomab} Immunology/Inflammation|{Moxetumomab} Protocol|{Moxetumomab} Formula|{Moxetumomab} supplier|{Moxetumomab} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC50 of 59 nM. Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.|Product information|CAS Number: 1338812-36-4|Molecular Weight: 416.90|Formula: C21H25ClN4O3|Chemical Name: N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxamide|Smiles: CC1(C)C(NC(=O)C2C=NN(CCO)C=2)C(C)(C)C1OC1=CC(Cl)=C(C=C1)C#N|InChiKey: HJJNHDLYWZTKGQ-UHFFFAOYSA-N|InChi: InChI=1S/C21H25ClN4O3/c1-20(2)18(25-17(28)14-11-24-26(12-14)7-8-27)21(3,4)19(20)29-15-6-5-13(10-23)16(22)9-15/h5-6,9,11-12,18-19,27H,7-8H2,1-4H3,(H,25,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Roxadustat} medchemexpress|{Roxadustat} Ferroptosis|{Roxadustat} Technical Information|{Roxadustat} Data Sheet|{Roxadustat} manufacturer|{Roxadustat} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:23903683 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Androgen receptor antagonist 1 (Compound 26; 1 nM-100 μM) shows significant cell growth inhibition effects for LNCaP and LNAR cells but not DU145 cells.|In Vivo:|Androgen receptor antagonist 1 (Compound 26; 100 mg/kg once a day for 5 weeks) demonstrates excellent in vivo tumor growth inhibition upon oral administration in a castration-resistant prostate cancer (CRPC) animal model.|Products are for research use only. Not for human use.|