Product Name :
BAY 1436032
Description:
BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants.
CAS:
1803274-65-8
Molecular Weight:
489.53
Formula:
C26H30F3N3O3
Chemical Name:
3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-(3,3,5-trimethylcyclohexyl)-1H-1,3-benzodiazol-5-yl)propanoic acid
Smiles :
CC1(C)CC(CC(C)C1)N1C(NC2C=CC(=CC=2)OC(F)(F)F)=NC2C=C(CCC(O)=O)C=CC1=2
InChiKey:
RNMAUIMMNAHKQR-UHFFFAOYSA-N
InChi :
InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1).{{Pitavastatin} site|{Pitavastatin} Autophagy|{Pitavastatin} Biological Activity|{Pitavastatin} Data Sheet|{Pitavastatin} supplier|{Pitavastatin} Epigenetic Reader Domain} It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants.{{Nemonoxacin} site|{Nemonoxacin} Anti-infection|{Nemonoxacin} Biological Activity|{Nemonoxacin} Formula|{Nemonoxacin} supplier|{Nemonoxacin} Epigenetics} |Product information|CAS Number: 1803274-65-8|Molecular Weight: 489.PMID:24275718 53|Formula: C26H30F3N3O3|Chemical Name: 3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-(3,3,5-trimethylcyclohexyl)-1H-1,3-benzodiazol-5-yl)propanoic acid|Smiles: CC1(C)CC(CC(C)C1)N1C(NC2C=CC(=CC=2)OC(F)(F)F)=NC2C=C(CCC(O)=O)C=CC1=2|InChiKey: RNMAUIMMNAHKQR-UHFFFAOYSA-N|InChi: InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C). 98 mg/mL(200.19 mM). Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants.|In Vivo:|The pharmacokinetic properties of BAY 1436032 allow for oral administration. In vivo pharmacokinetics (PK) in rats shows low CL and high oral bioavailability. Oral administration of BAY 1436032 confers a survival benefit to mice transplanted with IDH1 mutant tumors. BAY 1436032 induces differentiation in intracranial xenografts.|Products are for research use only. Not for human use.|