Product Name :
Midostaurin-D5
Description:
Midostaurin-D5 (PKC412-D5) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM.
CAS:
Molecular Weight:
575.67
Formula:
C35H30N4O4
Chemical Name:
N-[(2S,3R,4R,6R)-6-hydrogenio-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8,10,12,14(28),15(19),20(27),21(26),22,24-nonaen-4-yl]-N-methyl(²H₅)benzamide
Smiles :
[2H]C1=C(C(=O)N(C)[C@@H]2C[C@H]3O[C@@](C)([C@@H]2OC)N2C4=C(C5C=CC=CC2=5)C2CNC(=O)C=2C2=C4N3C3=CC=CC=C32)C([2H])=C([2H])C([2H])=C1[2H]
InChiKey:
BMGQWWVMWDBQGC-WBNDSJHMSA-N
InChi :
InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1/i4D,5D,6D,11D,12D
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vamorolone} web|{Vamorolone} NF-κB|{Vamorolone} Protocol|{Vamorolone} In Vitro|{Vamorolone} manufacturer|{Vamorolone} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Fosinopril} MedChemExpress|{Fosinopril} Metabolic Enzyme/Protease|{Fosinopril} Biological Activity|{Fosinopril} Description|{Fosinopril} manufacturer|{Fosinopril} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35991869
Additional information:
Midostaurin-D5 (PKC412-D5) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM.|Product information|Molecular Weight: 575.67|Formula: C35H30N4O4|Chemical Name: N-[(2S,3R,4R,6R)-6-hydrogenio-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8,10,12,14(28),15(19),20(27),21(26),22,24-nonaen-4-yl]-N-methyl(²H₅)benzamide|Smiles: [2H]C1=C(C(=O)N(C)[C@@H]2C[C@H]3O[C@@](C)([C@@H]2OC)N2C4=C(C5C=CC=CC2=5)C2CNC(=O)C=2C2=C4N3C3=CC=CC=C32)C([2H])=C([2H])C([2H])=C1[2H]|InChiKey: BMGQWWVMWDBQGC-WBNDSJHMSA-N|InChi: InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1/i4D,5D,6D,11D,12D|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|