Product Name :
CYT387 (sulfate salt)

Description:
Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.

CAS:
1056636-06-6

Molecular Weight:
610.62

Formula:
C23H26N6O10S2

Chemical Name:
N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide; bis(sulfuric acid)

Smiles :
N#CCNC(=O)C1C=CC(=CC=1)C1=CC=NC(NC2=CC=C(C=C2)N2CCOCC2)=N1.OS(O)(=O)=O.OS(O)(=O)=O

InChiKey:
XJGPMRGWDSQVTN-UHFFFAOYSA-N

InChi :
InChI=1S/C23H22N6O2.2H2O4S/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29;2*1-5(2,3)4/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28);2*(H2,1,2,3,4)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥360 days if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.|Product information|CAS Number: 1056636-06-6|Molecular Weight: 610.62|Formula: C23H26N6O10S2|Chemical Name: N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide; bis(sulfuric acid)|Smiles: N#CCNC(=O)C1C=CC(=CC=1)C1=CC=NC(NC2=CC=C(C=C2)N2CCOCC2)=N1.OS(O)(=O)=O.OS(O)(=O)=O|InChiKey: XJGPMRGWDSQVTN-UHFFFAOYSA-N|InChi: InChI=1S/C23H22N6O2.2H2O4S/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29;2*1-5(2,3)4/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28);2*(H2,1,2,3,4)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bergamottin} site|{Bergamottin} Cytochrome P450|{Bergamottin} Biological Activity|{Bergamottin} Data Sheet|{Bergamottin} manufacturer|{Bergamottin} Epigenetic Reader Domain} |Shelf Life: ≥360 days if stored properly.{{Raltitrexed} MedChemExpress|{Raltitrexed} Cell Cycle/DNA Damage|{Raltitrexed} Protocol|{Raltitrexed} Description|{Raltitrexed} manufacturer|{Raltitrexed} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23008002 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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