Product Name :
AM580
Description:
AM-580 is a potent RARalpha agonist. AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 inhibited the wnt pathway, measured by loss of nuclear beta-catenin, suggesting partial oncogene dependence of therapy. Am580 treatment increased RARbeta and lowered the level of RARgamma, an isotype whose expression we linked with tumor proliferation. Specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer.
CAS:
102121-60-8
Molecular Weight:
351.44
Formula:
C22H25NO3
Chemical Name:
4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-amido)benzoic acid
Smiles :
CC1(C)CCC(C)(C)C2=CC(=CC=C12)C(=O)NC1C=CC(=CC=1)C(O)=O
InChiKey:
SZWKGOZKRMMLAJ-UHFFFAOYSA-N
InChi :
InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AM-580 is a potent RARalpha agonist. AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 inhibited the wnt pathway, measured by loss of nuclear beta-catenin, suggesting partial oncogene dependence of therapy. Am580 treatment increased RARbeta and lowered the level of RARgamma, an isotype whose expression we linked with tumor proliferation. Specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer.|Product information|CAS Number: 102121-60-8|Molecular Weight: 351.44|Formula: C22H25NO3|Chemical Name: 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-amido)benzoic acid|Smiles: CC1(C)CCC(C)(C)C2=CC(=CC=C12)C(=O)NC1C=CC(=CC=1)C(O)=O|InChiKey: SZWKGOZKRMMLAJ-UHFFFAOYSA-N|InChi: InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lornoxicam} site|{Lornoxicam} TNF Receptor|{Lornoxicam} Protocol|{Lornoxicam} Description|{Lornoxicam} manufacturer|{Lornoxicam} Epigenetics} |Shelf Life: ≥360 days if stored properly.{{(-)-Ketoconazole} web|{(-)-Ketoconazole} Fungal|{(-)-Ketoconazole} Biological Activity|{(-)-Ketoconazole} In stock|{(-)-Ketoconazole} manufacturer|{(-)-Ketoconazole} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24458656 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|