Product Name :
Deltarasin — KRAS-PDEδ Inhibitor
Description:
Deltarasin is the potent and selective small molecular inhibitor of KRAS-PDEδ interaction, selectively binds to the prenyl-binding pocket of PDEδ with 38 nM affinity. It can inhibit oncogenic RAS signaling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. Correct localization and signaling by farnesylated KRAS is regulated by the prenyl-binding protein PDEδ, which sustains the spatial organization of KRAS by facilitating its diffusion in the cytoplasm. Deltarasin provides a novel opportunity to suppress oncogenic RAS signaling by altering its localization to endomembranes, and may inspire novel drug discovery efforts aimed at the development of drugs targeting oncogenic RAS.
CAS:
1440898-61-2
Molecular Weight:
603.75
Formula:
C40H37N5O
Chemical Name:
(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole
Smiles :
C(C1C=CC=CC=1)N1C(=NC2=CC=CC=C12)C1C=CC(=CC=1)OC[C@H](C1CCNCC1)N1C(=NC2=CC=CC=C12)C1C=CC=CC=1
InChiKey:
LTZKEDSUXKTTTC-KXQOOQHDSA-N
InChi :
InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Deltarasin is the potent and selective small molecular inhibitor of KRAS-PDEδ interaction, selectively binds to the prenyl-binding pocket of PDEδ with 38 nM affinity. It can inhibit oncogenic RAS signaling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. Correct localization and signaling by farnesylated KRAS is regulated by the prenyl-binding protein PDEδ, which sustains the spatial organization of KRAS by facilitating its diffusion in the cytoplasm. Deltarasin provides a novel opportunity to suppress oncogenic RAS signaling by altering its localization to endomembranes, and may inspire novel drug discovery efforts aimed at the development of drugs targeting oncogenic RAS.|Product information|CAS Number: 1440898-61-2|Molecular Weight: 603.75|Formula: C40H37N5O|Chemical Name: (S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole|Smiles: C(C1C=CC=CC=1)N1C(=NC2=CC=CC=C12)C1C=CC(=CC=1)OC[C@H](C1CCNCC1)N1C(=NC2=CC=CC=C12)C1C=CC=CC=1|InChiKey: LTZKEDSUXKTTTC-KXQOOQHDSA-N|InChi: InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1|Technical Data|Appearance: Solid Power.{{Thymidine 5′-monophosphate p-nitrophenyl ester} MedChemExpress|{Thymidine 5′-monophosphate p-nitrophenyl ester} Metabolic Enzyme/Protease|{Thymidine 5′-monophosphate p-nitrophenyl ester} Immunology/Inflammation|{Thymidine 5′-monophosphate p-nitrophenyl ester} Technical Information|{Thymidine 5′-monophosphate p-nitrophenyl ester} In stock|{Thymidine 5′-monophosphate p-nitrophenyl ester} supplier} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Verapamil} MedChemExpress|{Verapamil} Membrane Transporter/Ion Channel|{Verapamil} Protocol|{Verapamil} Description|{Verapamil} supplier|{Verapamil} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:22943596 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Deltarasin was used at 5 µM final concentration in various in vitro assays.|In Vivo:|Deltarasin was dosed to mice bearing Panc-Tu-I xenografts via intra-peritoneal (IP) injection at 10 mg/kg once or twice per day. Formulation is Lipovenoes 10% PLR and 5% DMSO.|References:|Zimmermann G, et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. (2013) Nature. 497(7451):638-42.Products are for research use only. Not for human use.|Documents||