Product Name :
Ro 32-0432 hydrochloride
Description:
Ro 32-0432 hydrochloride is a potent, selective, ATP-competitive and orally active PKC inhibitor. It is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. Ro 32-0432 hydrochloride prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases treatment.
CAS:
1781828-85-0
Molecular Weight:
489.01
Formula:
C28H29ClN4O2
Chemical Name:
(S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
Smiles :
Cl.CN(C)C[C@@H]1CC2=C(C3=CC=CC=C3N2CC1)C1=C(C2=CN(C)C3=CC=CC=C32)C(=O)NC1=O
InChiKey:
HSPRASOZRZDELU-LMOVPXPDSA-N
InChi :
InChI=1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H/t17-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ro 32-0432 hydrochloride is a potent, selective, ATP-competitive and orally active PKC inhibitor. It is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. Ro 32-0432 hydrochloride prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases treatment.|Product information|CAS Number: 1781828-85-0|Molecular Weight: 489.01|Formula: C28H29ClN4O2|Synonym:|Ro 32-0432 hydrochloride|Chemical Name: (S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride|Smiles: Cl.CN(C)C[C@@H]1CC2=C(C3=CC=CC=C3N2CC1)C1=C(C2=CN(C)C3=CC=CC=C32)C(=O)NC1=O|InChiKey: HSPRASOZRZDELU-LMOVPXPDSA-N|InChi: InChI=1S/C28H28N4O2.{{GM-CSF Protein, Mouse} medchemexpress|{GM-CSF Protein, Mouse} Biological Activity|{GM-CSF Protein, Mouse} Data Sheet|{GM-CSF Protein, Mouse} custom synthesis|{GM-CSF Protein, Mouse} Cancer} ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H/t17-;/m0.{{Aducanumab} site|{Aducanumab} Neuronal Signaling|{Aducanumab} Purity & Documentation|{Aducanumab} Purity|{Aducanumab} manufacturer|{Aducanumab} Epigenetics} /s1|Technical Data|Appearance: Solid Power.PMID:23829314 |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Ro 32-0432 inhibits interleukin-2 (IL-2) secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Ro 32-0432. Ro 32-0432 inhibits HA27 proliferation with an IC50 of 0.15 μM.|In Vivo:|Ro 32-0432 (10-50 mg/kg; oral administration; once; female AHH/R rats) treatment inhibits subsequent phorbol ester-induced edema in rats demonstrating the systemic efficacy of the compound to inhibit PKC-driven responses. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Ro 32-0432.|References:|Birchall AM, Bishop J, Bradshaw D, et al. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J Pharmacol Exp Ther. 1994;268(2):922-929.Singh TG, Rehni AK, Arora S. Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(3):197-204. doi:10.1007/s00210-012-0825-0.Products are for research use only. Not for human use.|