Product Name :
Candoxatril
Description:
Candoxatril is a neutral endopeptidase (NEP) inhibitor.
CAS:
123122-55-4
Molecular Weight:
515.64
Formula:
C29H41NO7
Chemical Name:
(1s,4s)-4-{1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentaneamido}cyclohexane-1-carboxylic acid
Smiles :
COCCOC[C@H](CC1(CCCC1)C(=O)N[C@@H]1CC[C@@H](CC1)C(O)=O)C(=O)OC1C=C2CCCC2=CC=1
InChiKey:
ZTWZVMIYIIVABD-OEMFJLHTSA-N
InChi :
InChI=1S/C29H41NO7/c1-35-15-16-36-19-23(27(33)37-25-12-9-20-5-4-6-22(20)17-25)18-29(13-2-3-14-29)28(34)30-24-10-7-21(8-11-24)26(31)32/h9,12,17,21,23-24H,2-8,10-11,13-16,18-19H2,1H3,(H,30,34)(H,31,32)/t21-,23-,24+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tiragolumab} medchemexpress|{Tiragolumab} Technical Information|{Tiragolumab} Purity|{Tiragolumab} supplier|{Tiragolumab} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Candoxatril is a neutral endopeptidase (NEP) inhibitor.|Product information|CAS Number: 123122-55-4|Molecular Weight: 515.64|Formula: C29H41NO7|Chemical Name: (1s,4s)-4-{1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentaneamido}cyclohexane-1-carboxylic acid|Smiles: COCCOC[C@H](CC1(CCCC1)C(=O)N[C@@H]1CC[C@@H](CC1)C(O)=O)C(=O)OC1C=C2CCCC2=CC=1|InChiKey: ZTWZVMIYIIVABD-OEMFJLHTSA-N|InChi: InChI=1S/C29H41NO7/c1-35-15-16-36-19-23(27(33)37-25-12-9-20-5-4-6-22(20)17-25)18-29(13-2-3-14-29)28(34)30-24-10-7-21(8-11-24)26(31)32/h9,12,17,21,23-24H,2-8,10-11,13-16,18-19H2,1H3,(H,30,34)(H,31,32)/t21-,23-,24+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tofisopam} web|{Tofisopam} Biological Activity|{Tofisopam} In Vitro|{Tofisopam} manufacturer|{Tofisopam} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:23618405 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor.|Products are for research use only. Not for human use.|