Product Name :
Tetromycin A
Description:
Tetromycin A, as an unusual tetronic acid, is a tetronic acid-based antibiotic. It is structurally related to saccharocarcin, chlorothricin, tetrocarcin, kijanimicin and versipelostatin and has been shown to be active against antibiotic resistant and susceptible Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). MRSA is a strain of bacteria which cannot be killed by a wide range of antibiotics, including methicillin, penicillin, and oxacillin, and causes infections in different parts of the body. The derivatives of tetromycin have been found to inhibit the cysteine protease cathepsin L with Ki values in the low micromolar range and have anti-trypanosomal activity. Tetromycin A probably targets the phosphatidylinositide-3′-kinase/Akt signaling pathway. Akt, a downstream factor in the phosphatidylinositide-3′-kinase-dependent pathway, mediates a variety of biological responses, including protein synthesis, glucose uptake and the regulation of proliferation and apoptosis, which presumably contributes to acquisition of malignant properties of human cancers . In vitro: Up to now, in vitro study of Tetromycin A is still in the development stage. In vivo: Up to now, in vivo study of Tetromycin A is still in the development stage.
CAS:
180027-83-2
Molecular Weight:
576.76
Formula:
C36H48O6
Chemical Name:
(1S,3R,6R,13R,16S,17S,20S,21R,22S)-27-hydroxy-3,4,6,8,12,14,20,22-octamethyl-23,25-dioxo-26-oxapentacyclo[22.2.1.0¹,⁶.0¹³,²².0¹⁶,²¹]heptacosa-4,7,11,14,24(27)-pentaen-17-yl acetate
Smiles :
CC(=O)O[C@H]1CC[C@H](C)[C@@H]2[C@@H]1C=C(C)[C@H]1C(C)=CCCC(C)=C[C@]3(C)C=C(C)[C@H](C)C[C@@]43OC(=O)C(=C4O)C(=O)[C@@]21C |t:17,22|
InChiKey:
UZJGZPDDMTVQTD-NCZGMQCYSA-N
InChi :
InChI=1S/C36H48O6/c1-19-11-10-12-20(2)29-22(4)15-26-27(41-25(7)37)14-13-21(3)30(26)35(29,9)31(38)28-32(39)36(42-33(28)40)18-24(6)23(5)17-34(36,8)16-19/h12,15-17,21,24,26-27,29-30,39H,10-11,13-14,18H2,1-9H3/b19-16-,20-12-/t21-,24+,26+,27-,29+,30+,34+,35+,36+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Gramicidin} medchemexpress|{Gramicidin} Anti-infection|{Gramicidin} Biological Activity|{Gramicidin} In Vivo|{Gramicidin} manufacturer|{Gramicidin} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Rituximab (anti-CD20)} web|{Rituximab (anti-CD20)} Immunology/Inflammation|{Rituximab (anti-CD20)} Activator|{Rituximab (anti-CD20)} Biological Activity|{Rituximab (anti-CD20)} Description|{Rituximab (anti-CD20)} custom synthesis}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tetromycin A, as an unusual tetronic acid, is a tetronic acid-based antibiotic. It is structurally related to saccharocarcin, chlorothricin, tetrocarcin, kijanimicin and versipelostatin and has been shown to be active against antibiotic resistant and susceptible Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).PMID:29844565 MRSA is a strain of bacteria which cannot be killed by a wide range of antibiotics, including methicillin, penicillin, and oxacillin, and causes infections in different parts of the body. The derivatives of tetromycin have been found to inhibit the cysteine protease cathepsin L with Ki values in the low micromolar range and have anti-trypanosomal activity. Tetromycin A probably targets the phosphatidylinositide-3′-kinase/Akt signaling pathway. Akt, a downstream factor in the phosphatidylinositide-3′-kinase-dependent pathway, mediates a variety of biological responses, including protein synthesis, glucose uptake and the regulation of proliferation and apoptosis, which presumably contributes to acquisition of malignant properties of human cancers . In vitro: Up to now, in vitro study of Tetromycin A is still in the development stage. In vivo: Up to now, in vivo study of Tetromycin A is still in the development stage.|Product information|CAS Number: 180027-83-2|Molecular Weight: 576.76|Formula: C36H48O6|Chemical Name: (1S,3R,6R,13R,16S,17S,20S,21R,22S)-27-hydroxy-3,4,6,8,12,14,20,22-octamethyl-23,25-dioxo-26-oxapentacyclo[22.2.1.0¹,⁶.0¹³,²².0¹⁶,²¹]heptacosa-4,7,11,14,24(27)-pentaen-17-yl acetate|Smiles: CC(=O)O[C@H]1CC[C@H](C)[C@@H]2[C@@H]1C=C(C)[C@H]1C(C)=CCCC(C)=C[C@]3(C)C=C(C)[C@H](C)C[C@@]43OC(=O)C(=C4O)C(=O)[C@@]21C |t:17,22||InChiKey: UZJGZPDDMTVQTD-NCZGMQCYSA-N|InChi: InChI=1S/C36H48O6/c1-19-11-10-12-20(2)29-22(4)15-26-27(41-25(7)37)14-13-21(3)30(26)35(29,9)31(38)28-32(39)36(42-33(28)40)18-24(6)23(5)17-34(36,8)16-19/h12,15-17,21,24,26-27,29-30,39H,10-11,13-14,18H2,1-9H3/b19-16-,20-12-/t21-,24+,26+,27-,29+,30+,34+,35+,36+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|