Product Name :
T-91825
Description:
T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria.
CAS:
189345-04-8
Molecular Weight:
604.70
Formula:
C22H20N8O5S4
Chemical Name:
4-(2-{[(6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)-1-methylpyridin-1-ium
Smiles :
CCO/N=C(/C1N=C(N)SN=1)\C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3C=C[N+](C)=CC=3)=C(C([O-])=O)N2C1=O
InChiKey:
RGFBRLNVZCCMSV-BIRGHMBHSA-N
InChi :
InChI=1S/C22H20N8O5S4/c1-3-35-27-13(16-26-21(23)39-28-16)17(31)25-14-18(32)30-15(20(33)34)12(9-36-19(14)30)38-22-24-11(8-37-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H3-,23,25,26,28,31,33,34)/b27-13-/t14-,19-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Famotidine} medchemexpress|{Famotidine} Histamine Receptor|{Famotidine} Biological Activity|{Famotidine} In stock|{Famotidine} custom synthesis|{Famotidine} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Dihydroergotamine} web|{Dihydroergotamine} Neuronal Signaling|{Dihydroergotamine} Technical Information|{Dihydroergotamine} Formula|{Dihydroergotamine} manufacturer|{Dihydroergotamine} Epigenetics}
Additional information:
T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria.|Product information|CAS Number: 189345-04-8|Molecular Weight: 604.70|Formula: C22H20N8O5S4|Chemical Name: 4-(2-{[(6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)-1-methylpyridin-1-ium|Smiles: CCO/N=C(/C1N=C(N)SN=1)\C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3C=C[N+](C)=CC=3)=C(C([O-])=O)N2C1=O|InChiKey: RGFBRLNVZCCMSV-BIRGHMBHSA-N|InChi: InChI=1S/C22H20N8O5S4/c1-3-35-27-13(16-26-21(23)39-28-16)17(31)25-14-18(32)30-15(20(33)34)12(9-36-19(14)30)38-22-24-11(8-37-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H3-,23,25,26,28,31,33,34)/b27-13-/t14-,19-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32491513 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PPI-0903M is very active against S. aureus (MIC50=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC50=1 μg/mL). PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC50s ranging from 0.25 to 4 μg/mL.|In Vivo:|AK-599 (20 mg/kg; s.c. three times a day for 2 days) decreases the bacterial cell counts in lungs more than 99.9% in a mouse pneumonia model caused by MRSA.|Products are for research use only. Not for human use.|