Product Name :
ITX5061
Description:
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
CAS:
1252679-52-9
Molecular Weight:
620.16
Formula:
C30H38ClN3O7S
Chemical Name:
N-(5-tert-butyl-3-methanesulfonamido-2-methoxyphenyl)-2-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}-2-oxoacetamide hydrochloride
Smiles :
Cl.COC1C(=CC(=CC=1NS(C)(=O)=O)C(C)(C)C)NC(=O)C(=O)C1=CC=C(OCCN2CCOCC2)C2=CC=CC=C21
InChiKey:
ICIJBYYMEBOTQP-UHFFFAOYSA-N
InChi :
InChI=1S/C30H37N3O7S.ClH/c1-30(2,3)20-18-24(28(38-4)25(19-20)32-41(5,36)37)31-29(35)27(34)23-10-11-26(22-9-7-6-8-21(22)23)40-17-14-33-12-15-39-16-13-33;/h6-11,18-19,32H,12-17H2,1-5H3,(H,31,35);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).|Product information|CAS Number: 1252679-52-9|Molecular Weight: 620.16|Formula: C30H38ClN3O7S|Chemical Name: N-(5-tert-butyl-3-methanesulfonamido-2-methoxyphenyl)-2-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}-2-oxoacetamide hydrochloride|Smiles: Cl.COC1C(=CC(=CC=1NS(C)(=O)=O)C(C)(C)C)NC(=O)C(=O)C1=CC=C(OCCN2CCOCC2)C2=CC=CC=C21|InChiKey: ICIJBYYMEBOTQP-UHFFFAOYSA-N|InChi: InChI=1S/C30H37N3O7S.ClH/c1-30(2,3)20-18-24(28(38-4)25(19-20)32-41(5,36)37)31-29(35)27(34)23-10-11-26(22-9-7-6-8-21(22)23)40-17-14-33-12-15-39-16-13-33;/h6-11,18-19,32H,12-17H2,1-5H3,(H,31,35);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 83.3 mg/mL (134.32 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Inorganic pyrophosphatase} MedChemExpress|{Inorganic pyrophosphatase} Endonuclease|{Inorganic pyrophosphatase} Protocol|{Inorganic pyrophosphatase} Description|{Inorganic pyrophosphatase} supplier|{Inorganic pyrophosphatase} Epigenetic Reader Domain} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).{{S2116} web|{S2116} Histone Demethylase|{S2116} Protocol|{S2116} In Vivo|{S2116} manufacturer|{S2116} Epigenetic Reader Domain} Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline.PMID:32565113 ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (PReferences:|Masson D, et al. Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2054-60.Products are for research use only. Not for human use.|