Product Name :
(Z)-GW 5074
Description:
(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder.
CAS:
1233748-60-1
Molecular Weight:
520.94
Formula:
C15H8Br2INO2
Chemical Name:
(3Z)-3-[(3, 5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
Smiles :
OC1C(Br)=CC(=CC=1Br)C=C1C(=O)NC2=CC=C(I)C=C21
InChiKey:
LMXYVLFTZRPNRV-KMKOMSMNSA-N
InChi :
InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder.|Product information|CAS Number: 1233748-60-1|Molecular Weight: 520.{{Fmoc-Pro-OH} web|{Fmoc-Pro-OH} {Amino Acid Derivatives}|{Fmoc-Pro-OH} Technical Information|{Fmoc-Pro-OH} In Vivo|{Fmoc-Pro-OH} supplier|{Fmoc-Pro-OH} Autophagy} 94|Formula: C15H8Br2INO2|Chemical Name: (3Z)-3-[(3, 5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one|Smiles: OC1C(Br)=CC(=CC=1Br)C=C1C(=O)NC2=CC=C(I)C=C21|InChiKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N|InChi: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Thiazolidine} web|{Thiazolidine} {Drug Intermediate}|{Thiazolidine} Protocol|{Thiazolidine} In Vivo|{Thiazolidine} manufacturer|{Thiazolidine} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:32515917 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.Products are for research use only. Not for human use.|