Product Name :
AZD4205
Description:
AZD4205 is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM).
CAS:
2091134-68-6
Molecular Weight:
489.57
Formula:
C25H31N9O2
Chemical Name:
(2R)-N-(3-2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide
Smiles :
CN1CCN(CC1)[C@H](C)C(=O)NC1=CC=CC2=C1NC=C2C1C=CN=C(NC2=CN(C)N=C2OC)N=1
InChiKey:
CVCVOSPZEVINRM-MRXNPFEDSA-N
InChi :
InChI=1S/C25H31N9O2/c1-16(34-12-10-32(2)11-13-34)23(35)28-20-7-5-6-17-18(14-27-22(17)20)19-8-9-26-25(29-19)30-21-15-33(3)31-24(21)36-4/h5-9,14-16,27H,10-13H2,1-4H3,(H,28,35)(H,26,29,30)/t16-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Clindamycin Bacterial
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD4205 is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.α-Vitamin E Epigenetic Reader Domain 7 μM), and shows little inhibition on JAK3 (IC50>30 μM).|Product information|CAS Number: 2091134-68-6|Molecular Weight: 489.57|Formula: C25H31N9O2|Chemical Name: (2R)-N-(3-2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide|Smiles: CN1CCN(CC1)[C@H](C)C(=O)NC1=CC=CC2=C1NC=C2C1C=CN=C(NC2=CN(C)N=C2OC)N=1|InChiKey: CVCVOSPZEVINRM-MRXNPFEDSA-N|InChi: InChI=1S/C25H31N9O2/c1-16(34-12-10-32(2)11-13-34)23(35)28-20-7-5-6-17-18(14-27-22(17)20)19-8-9-26-25(29-19)30-21-15-33(3)31-24(21)36-4/h5-9,14-16,27H,10-13H2,1-4H3,(H,28,35)(H,26,29,30)/t16-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (510.PMID:33237691 65 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZD4205 (Example 32) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2, and shows little inhibition on JAK3 (IC50, >14.7, >30 μM, respectively). AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells with an IC50 of 161 nM.|In Vivo:|AZD4205 (12.5 mg/kg BID (twice daily), 25 m/kg BID or 50 mg/kg BID, p.o.) alone has increasing antitumor effects, and ehances the antitumor activity of osimertinib, compared to treatment with osimertinib alone in mice bearing NCI-H1975 cells.|Products are for research use only. Not for human use.|