Product Name :
QCA570
Description:
QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.
CAS:
2207569-08-0
Molecular Weight:
695.79
Formula:
C39H33N7O4S
Chemical Name:
3-(4-5-[4-(2-5-benzyl-13-methyl-8-oxa-3-thia-1,11,12-triazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,10,12-tetraen-4-ylethynyl)-1H-pyrazol-1-yl]pent-1-yn-1-yl-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
Smiles :
CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3C=CC=CC=3)N21
InChiKey:
RTVTYLRQKKDYMQ-UHFFFAOYSA-N
InChi :
InChI=1S/C39H33N7O4S/c1-25-42-43-35-24-50-23-32-30(19-26-9-4-2-5-10-26)34(51-39(32)46(25)35)16-14-27-20-40-44(21-27)18-7-3-6-11-28-12-8-13-29-31(28)22-45(38(29)49)33-15-17-36(47)41-37(33)48/h2,4-5,8-10,12-13,20-21,33H,3,7,15,17-19,22-24H2,1H3,(H,41,47,48)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.|Product information|CAS Number: 2207569-08-0|Molecular Weight: 695.79|Formula: C39H33N7O4S|Chemical Name: 3-(4-5-[4-(2-5-benzyl-13-methyl-8-oxa-3-thia-1,11,12-triazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,10,12-tetraen-4-ylethynyl)-1H-pyrazol-1-yl]pent-1-yn-1-yl-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione|Smiles: CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3C=CC=CC=3)N21|InChiKey: RTVTYLRQKKDYMQ-UHFFFAOYSA-N|InChi: InChI=1S/C39H33N7O4S/c1-25-42-43-35-24-50-23-32-30(19-26-9-4-2-5-10-26)34(51-39(32)46(25)35)16-14-27-20-40-44(21-27)18-7-3-6-11-28-12-8-13-29-31(28)22-45(38(29)49)33-15-17-36(47)41-37(33)48/h2,4-5,8-10,12-13,20-21,33H,3,7,15,17-19,22-24H2,1H3,(H,41,47,48)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 40 mg/mL (57.Darunavir site 49 mM; Need ultrasonic).Anti-HA tag Rabbit mAb Biological Activity |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33219878 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date.|Products are for research use only. Not for human use.|