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Open AccessResearchOverdetection in breast cancer screening development and preliminary evaluation of a selection aidJolyn Hersch, Jesse Jansen, Alexandra Barratt, Les Irwig, Nehmat Houssami, Gemma Thiophanate-Methyl Inhibitor Jacklyn, Hazel Thornton, Haryana Dhillon, Kirsten McCafferyTo cite Hersch J, Jansen J, Barratt A, et al.Overdetection in breast cancer screening development and preliminary evaluation of a decision aid.BMJ Open ;e.doi.bmjopen Prepublication history for this paper is offered online.To view these files please go to the journal on-line (dx.doi.org.bmjopen).Received July Revised August Accepted SeptemberABSTRACT Objective To create, pilot and refine a choice help(ahead of a randomised trial evaluation) for ladies about age facing their initial selection about no matter whether to undergo mammography screening.Design and style Twostage mixedmethod pilot study including qualitative interviews (n) as well as a randomised comparison applying a quantitative survey (n).Setting New South Wales, Australia.Participants Females aged years with no private history of breast cancer.Interventions The decision aid supplies evidencebased facts about crucial outcomes of mammography screening more than years (breast cancer mortality reduction, overdetection and false positives) compared with no screening.The information and facts is presented in a quick booklet for ladies, combining text and visual formats.A manage version made for the purposes of comparison omits the overdetectionrelated content material.Outcomes Comprehension of crucial decision aid content and acceptability of your materials.Results Most females regarded the choice aid clear and valuable and would suggest it to others.Nonetheless, the piloting course of action raised crucial troubles that we attempted PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21446885 to address in iterative revisions.Some participants discovered it difficult to fully grasp overdetection and why it can be of concern, although there was generally confusion about the distinction between overdetection and false positives.Within a screening context, encountering balanced information and facts rather than persuasion seems to be contrary to people’s expectations, but females appreciated the opportunity to grow to be improved informed.Conclusions The idea of overdetection is complicated and new towards the public.This study highlights some essential challenges for communicating about this concern.It is actually significant to clarify that overdetection differs from false positives with regards to its extra really serious consequences (overtreatment and associated harms).Screening choice aids also ought to clearly clarify their goal of facilitating informed choice.A staged method to development and piloting of decision aids is recommended to additional strengthen understanding of overdetection and support informed decisionmaking about screening.Strengths and limitations of this studyThe strengths of this project contain the staged, mixedmethods approach to building and evaluating the choice help, combining each qualitative and q.