g 1, Jun Yang two and Xu Zhang 11 Division of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Healthcare Epigenetics, Tianjin Medical University, Tianjin, China, 2 Division of Entomology and Nematology, University of California, Davis, Davis, CA, United StatesKeywords: bioactive lipid, eicosanoid, oxylipin, sphingolipid, lysophospholipid, metabolic diseases, cardiovascular illnesses, respiratory diseasesEditorial on Research Subject: The Part of Bioactive Lipids in Homeostasis and Pathology Bioactive lipids, including fatty acids and their metabolic solutions, acylglycerol derivatives, endocannabinoids, lysophospholipids, sphingolipids, and cholesterol metabolites, and so forth., play active roles in regulating cellular functions. They may be not only products of lipid metabolism, but additionally important signals in CYP11 Inhibitor site tissue homeostasis and pathology. The functions of a sizable quantity of bioactive lipids remain unclear. In addition, even the exact same lipid mediator reveals many functions by activating different receptors. Therefore, it truly is important to clarify the receptors and signal transduction HDAC11 Inhibitor Formulation capabilities of those lipids. The aim from the present Research Topic is usually to present a thorough overview on the function, signal transduction, and regulatory mechanisms of bioactive lipids. This Research Topic will provide insight into their effects on homeostasis and pathology. The current Research Subject involves six testimonials and five original investigation articles. These research focus on the effects of bioactive lipids in the homeostasis and pathology of the cardiovascular technique, respiratory method, liver, and adipose tissue dysfunction as well as other individuals (Figure 1). Arachidonic acid-derived eicosanoids, such as prostaglandins (PG), thromboxanes, leukotrienes, lipoxins, hydroxyeicosatetraenoic acids, and epoxyeicosatrienoic acids (EETs), among others, happen to be the focus of serious interest because of their essential roles in numerous physiological and pathophysiological processes. The roles of EETs and metabolites of arachidonic acid by cytochrome P450s were reviewed by Lai and Chen. This critique recommended that increasing the levels of EETs can be a prospective therapeutic strategy for cardiovascular illness (Lai and Chen). Cyclopentenone prostaglandins (cyPGs) are a cluster of PGs with a cyclopentenone ring structure. CyPGs (PGA1, PGA2, and PGJ2 and its’ metabolites) biosynthesis, mechanism of action, functions, and their effects on virus infection and cancer improvement have been discussed inside a review by Lee et al. In addition to arachidonic acid-derived eicosanoids, bioactive metabolites of -3 polyunsaturated fatty acids (PUFAs) have also drawn interest in recent years. Duan et al. summarized the effects of -3 PUFA-derived oxylipins on metabolic problems, such as diabetes, non-alcoholic fatty liver illness, adipose tissue dysfunction, and atherosclerosis. This review highlighted the significance of those derivatives when exploring the therapeutic effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Duan et al.). In addition, an original investigation short article reported that -3 PUFA treatment enhanced HHcy-induced insulin resistance and inflammasome activation in adipose tissue. HHcy improved lysophosphatidylcholine (LPC) 16:0 and LPC 18:0 levels in adipose tissue, which have been suppressed by -3 PUFA treatment. This study linked -3 PUFAs to lysophospholipid production (Li et al.). Because the key elements of edible oil, the roles of -6 PUFAs