Product Name :
FR194738
Description:
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
CAS:
204067-52-7
Molecular Weight:
476.11
Formula:
C27H38ClNO2S
Chemical Name:
[(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](ethyl)[(3-{2-methyl-2-[(thiophen-3-yl)methoxy]propoxy}phenyl)methyl]amine hydrochloride
Smiles :
Cl.CC(C)(C)C#C/C=C/CN(CC1=CC(=CC=C1)OCC(C)(C)OCC1C=CSC=1)CC
InChiKey:
XZCWZZDUAVANHV-VRTOBVRTSA-N
InChi :
InChI=1S/C27H37NO2S.ClH/c1-7-28(16-10-8-9-15-26(2,3)4)19-23-12-11-13-25(18-23)29-22-27(5,6)30-20-24-14-17-31-21-24;/h8,10-14,17-18,21H,7,16,19-20,22H2,1-6H3;1H/b10-8+;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.|Product information|CAS Number: 204067-52-7|Molecular Weight: 476.11|Formula: C27H38ClNO2S|Chemical Name: [(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](ethyl)[(3-{2-methyl-2-[(thiophen-3-yl)methoxy]propoxy}phenyl)methyl]amine hydrochloride|Smiles: Cl.CC(C)(C)C#C/C=C/CN(CC1=CC(=CC=C1)OCC(C)(C)OCC1C=CSC=1)CC|InChiKey: XZCWZZDUAVANHV-VRTOBVRTSA-N|InChi: InChI=1S/C27H37NO2S.ClH/c1-7-28(16-10-8-9-15-26(2,3)4)19-23-12-11-13-25(18-23)29-22-27(5,6)30-20-24-14-17-31-21-24;/h8,10-14,17-18,21H,7,16,19-20,22H2,1-6H3;1H/b10-8+;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Gemifloxacin} MedChemExpress|{Gemifloxacin} Bacterial|{Gemifloxacin} Purity & Documentation|{Gemifloxacin} References|{Gemifloxacin} custom synthesis|{Gemifloxacin} Cancer} |Shelf Life: ≥12 months if stored properly.{{FH1} site|{FH1} Purity & Documentation|{FH1} Description|{FH1} manufacturer|{FH1} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:27102143 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In intact HepG2 cells|In Vivo:|Serum lipid levels in hamsters after daily administration of FR194738 and Pravastatin for 10 d are measured. FR194738 reduces the serum levels of total, non high density lipoprotein (HDL) and HDL cholesterol, and triglyceride. Treatment of hamsters with FR194738 increases HMG-CoA reductase activity by 1.3-fold at 32 mg/kg compared to the control group and does not significantly change that at 100 mg/kg.|Products are for research use only. Not for human use.|