Product Name :
GBR 12783
Description:
GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats.
CAS:
67469-57-2
Molecular Weight:
412.57
Formula:
C28H32N2O
Chemical Name:
1-[2-(diphenylmethoxy)ethyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Smiles :
C(/C=C/C1C=CC=CC=1)N1CCN(CCOC(C2C=CC=CC=2)C2C=CC=CC=2)CC1
InChiKey:
XFBDGHFDKJITGC-JLHYYAGUSA-N
InChi :
InChI=1S/C28H32N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-17,28H,18-24H2/b13-10+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Sertraline} site|{Sertraline} Serotonin Transporter|{Sertraline} Protocol|{Sertraline} Data Sheet|{Sertraline} manufacturer|{Sertraline} Epigenetic Reader Domain}
Additional information:
GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.{{Prodan} medchemexpress|{Prodan} {Fluorescent Dye}|{Prodan} Purity & Documentation|{Prodan} Description|{Prodan} custom synthesis|{Prodan} Epigenetics} 8 nM and 1.PMID:32897886 2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats.|Product information|CAS Number: 67469-57-2|Molecular Weight: 412.57|Formula: C28H32N2O|Chemical Name: 1-[2-(diphenylmethoxy)ethyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine|Smiles: C(/C=C/C1C=CC=CC=1)N1CCN(CCOC(C2C=CC=CC=2)C2C=CC=CC=2)CC1|InChiKey: XFBDGHFDKJITGC-JLHYYAGUSA-N|InChi: InChI=1S/C28H32N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-17,28H,18-24H2/b13-10+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.|Products are for research use only. Not for human use.|