Product Name :
SB239063
Sequence:
Purity:
≥97% (HPLC)
Molecular Weight:
368.4
Solubility :
Soluble in DMSO, 100% ethanol or dichlormethane (may require slight warming).
Appearance:
White to off-white solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended.
Description:
p38 inhibitor A potent, cell permeable inhibitor of p38 MAP kinase (IC50=44nM for recombinant purified human p38α). Inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes (IC50=120nM and 350nM, respectively). Reported to protect against mild excitotoxic neuronal injury caused by NMDA and provides substantial protection against cell death induced by either oxygen glucose deprivation (OGD) or magnesium deprivation in cultured neurons.2374782-02-0 Protocol Also, reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of polymorphonuclear (PMN) accumulation.2446803-65-0 In Vivo
CAS :
193551-21-2
Solubility:
Soluble in DMSO, 100% ethanol or dichlormethane (may require slight warming).PMID:30000897
Formula:
C20H21FN4O2
Additional Information :
| Alternative Name trans-1-(4-Hydroxycyclohexyl)-4-(fluorophenyl)-5-(2-methoxypyrimidin-4-yl) imidazole | Appearance White to off-white solid. | CAS 193551-21-2 | Couple Target p38 | Couple Type Inhibitor | Formula C20H21FN4O2 | Identity Identity determined by 1H-NMR. | MW 368.4 | Purity ≥97% (HPLC) | Solubility Soluble in DMSO, 100% ethanol or dichlormethane (may require slight warming). | Unit of Measure (UM) mg, µg