tes the CSC-like features of breast cancer cells. Recent studies indicate that a subset 11325787 effect of TGFb-dependent 14-3-3s phosphorylation on Smad3-dependent transcription. The overexpression of the wild type 14-3-3s…
or with t-, t- and MLL-rearranged subtypes. The centroid plots for each miRNA is given as well as the predictive statistics from 10fold cross-validation. Se, Sensitivity as positively predicted vs.…
direction of their transcriptional regulation throughout the time-course. The first and 16494499 response and their regulation, such as Interleukin -1, IL-2, IL-3, IL-4, IL-5, IL-7 and IL-9 pathways, CD40 pathway,…
f 14-3-3s phosphorylation at Ser69 and Ser74 residues. We also observed co-localization of Smad3 and wild-type 14-3-3s in cells using immunofluorescence staining. Thus, the interaction of Smad3 and 14-3-3s requires…
patients, particularly those with a PKD2 genotype. We therefore wondered whether urinary proteomics might be useful for ADPKD diagnosis in this patient group. However, similar to the accuracy of ultrasound…
they were all chronically infected with HCV. Those with a FIB-4 score greater than 3.25 were identified as having moderate to severe liver disease. Other conditions identified in one or…
eral location of the centrosome at the interface with the substrate. A predicted cell structure belonging to this second mode of the distribution is shown in Fig. 4CD. It approximates…
me that this membrane perturbation is not sufficient to explain tubes formation or membrane aggregation. The basic residues in the surface must be in the right positions to induce membrane…
ant role in tumor progression; however, their role in CAFs and cancer cells is different. A recent finding of Sanchez-Alvarez and colleagues suggests that mitochondrial dysfunction in CAFs promotes tumor…
n Unc45b and other cytosolic components, including Hsp90. Immunoprecipitation of the endogenous Unc45b from the C2C12 lysate with the anti-Unc45b antibody demonstrates that it is indeed a complex with Hsp90…